EFFECT OF SUPERIOR COLLICULUS LESIONS ON SENSORY UNIT RESPONSES IN THE INTRALAMINAR THALAMUS OF THE RAT

被引:24
作者
KRAUTHAMER, GM
KROL, JG
GRUNWERG, BS
机构
[1] Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway
关键词
INTRALAMINAR THALAMUS; SENSORY INPUT; SUPERIOR COLLICULUS LESION; KAINIC ACID; EXTRACELLULAR UNIT; RAT;
D O I
10.1016/0006-8993(92)90691-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effects of kainic acid lesions of the intermediate and deep layers of the superior colliculus on the sensory input to the intralaminar thalamus of the rat were determined. Ipsiversive circling and contralateral sensory neglect were consistently seen after lesion placement. Two to 7 days later, the intralaminar thalamus was systematically explored for extracellular mechanoreceptive unit responses to high threshold and low threshold stimuli. On the side ipsilateral to the lesion the number of responsive units was reduced by 51%. The loss was particularly marked for nociceptive units (80%), and low threshold and complex units with orofacial receptive fields (73%). This effect may involve a partial deafferentation of the intralaminar thalamus as well as altered excitatory thresholds of thalamic neurons. It is suggested that the functionally distinct direct tectothalamic projection as well as the indirect tecto-reticulo-thalamic pathway are implicated.
引用
收藏
页码:277 / 286
页数:10
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