NANOCRYSTALLINE EPSTEIN-BARR-VIRUS DECOYS

被引：14

作者：

KOSSOVSKY, N

GELMAN, A

SPONSLER, E

MILLETT, D

机构：

[1] Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Angeles

来源：

JOURNAL OF APPLIED BIOMATERIALS | 1991年 / 2卷 / 04期

关键词：

D O I：

10.1002/jab.770020406

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A novel biotechnology is introduced by way of the successful synthesis of nanocrystalline Epstein-Barr virus (EBV) decoys having specific in vivo immunogenic activity. Assembled from ultrafine surface modified tin oxide and purified DNA-free isolated EBV envelope proteins, the decoys consisted of < 150 nm units whose electrophoretic mobilities were similar to whole EBV; whose outer coats were strongly immunoreactive with murine monoclonal anti-EBV antibodies; and which elicited immunospecific neutralizing anti-EBV antibodies in the rabbit. The development of this carrier technology for vaccine preparations is suggested.

引用

页码：251 / 259

页数：9

共 19 条

[1] ANTI-VIRAL RESPONSE ELICITED BY A COMPLETELY SYNTHETIC ANTIGEN WITH BUILT-IN ADJUVANTICITY
ARNON, R
SELA, M
PARANT, M
CHEDID, L
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (11): : 6769 - 6772
[2] CELADA F, 1987, SYNTHETIC VACCINES, V1, P117
[3] CHANOCK RM, 1984, P COLD SPRING HARBOR
[4] CHEDID L, 1987, SYNTHETIC VACCINES, V1, P93
[5] Epstein M., 1979, EPSTEINBARR VIRUS, P321, DOI 10.1007/978-3-642-67236-1_14
[6] FAULK WP, 1971, IMMUNOCHEMISTRY, V8, P1081
[7] GELL PGH, 1959, IMMUNOLOGY, V2, P64
[8] RELATION OF BURKITTS TUMOR-ASSOCIATED HERPES-TYPE VIRUS TO INFECTIOUS MONONUCLEOSIS
HENLE, G
HENLE, W
DIEHL, V
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1968, 59 (01) : 94 - &
[9] HEWETSON JF, 1973, J INFECT DIS, V128, P283, DOI 10.1093/infdis/128.3.283
[10] A NONDENATURING SOLID-PHASE PHARMACEUTICAL CARRIER COMPRISED OF SURFACE-MODIFIED NANOCRYSTALLINE MATERIALS
KOSSOVSKY, N
BUNSHAH, RF
GELMAN, A
SPONSLER, E
UMARJEE, DM
SUH, TG
PRAKASH, S
DOERR, HJ
DESHPANDEY, CV
[J]. JOURNAL OF APPLIED BIOMATERIALS, 1990, 1 (04) : 289 - 294

← 1 2 →