ACELLULAR PERTUSSIS-VACCINE COMPOSED OF GENETICALLY INACTIVATED PERTUSSIS TOXIN - SAFETY AND IMMUNOGENICITY IN 12-MONTH-OLD TO 24-MONTH-OLD AND 2-MONTH-OLD TO 4-MONTH-OLD CHILDREN

被引:34
作者
PODDA, A
DELUCA, EC
TITONE, L
CASADEI, AM
CASCIO, A
PEPPOLONI, S
VOLPINI, G
MARSILI, I
NENCIONI, L
RAPPUOLI, R
机构
[1] BIOCINE SCLAVO R&D VACCINES, VIA FIORENTINA 1, I-53100 SIENNA, ITALY
[2] UNIV ROME LA SAPIENZA, IST PUERICULTURA, I-00185 ROME, ITALY
[3] UNIV PALERMO, MALATTIE INFETT CLIN, I-90134 PALERMO, ITALY
关键词
D O I
10.1016/S0022-3476(05)80227-6
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
To determine whether a nontoxic derivative of pertussis toxin obtained by recombinant DNA technology, PT-9K/129G, is a good candidate for a new pertussis vaccine, we examined the safety and the immunogenicity in children of a vaccine containing 15-mu-g of PT-9K/129G protein and 0.5 mg of aluminum hydroxide per dose. Fifty-three children 12 to 24 months of age and 21 infants aged 2 to 4 months were injected with two and three doses, respectively. The vaccine did not induce significant local or systemic reactions and elicited an increase of antibody titer in more than 98% of the children. The geometric mean of the toxin-neutralizing titers increased after each dose and was 85 units in children given two doses and 196 units in those given three doses. Two children who had detectable antibody levels before the first immunization had a high response ( > 320 units) to the first vaccine dose. The findings suggest that PT-9K/129G is a promising antigen to be included in the development of acellular pertussis vaccines.
引用
收藏
页码:680 / 685
页数:6
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