CONCEPTS AND STRATEGIES FOR HUMAN GENE-THERAPY

被引:75
作者
ROEMER, K [1 ]
FRIEDMANN, T [1 ]
机构
[1] UNIV CALIF SAN DIEGO, CTR MOLEC GENET, LA JOLLA, CA 92093 USA
来源
EUROPEAN JOURNAL OF BIOCHEMISTRY | 1992年 / 208卷 / 02期
关键词
D O I
10.1111/j.1432-1033.1992.tb17176.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Methods of modem molecular genetics have been developed that allow stable transfer and expression of foreign DNA sequences in human and other mammalian somatic cells. It is therefore no surprise that the methods have been applied in attempts to complement genetic defects and correct disease phenotypes. Two decades of research have now led to the first clinically applicable attempts to introduce genetically modified cells into human beings to cure diseases caused at least partially by genetic defects. We discuss here some of the strategies being followed for both in vitro and in vivo application of therapeutic gene transfer and summarize some of the technical and conceptual difficulties associated with somatic-cell gene therapy.
引用
收藏
页码:211 / 225
页数:15
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