EFFECTS OF CHLORHEXIDINE DIACETATE ON CANDIDA-ALBICANS, C-GLABRATA AND SACCHAROMYCES-CEREVISIAE

被引：34

作者：

HIOM, SJ

FURR, JR

RUSSELL, AD

DICKINSON, JR

机构：

[1] UNIV WALES COLL CARDIFF,WELSH SCH PHARM,POB 13,CARDIFF CF1 3XF,WALES

[2] UNIV WALES COLL CARDIFF,SCH PURE & APPL BIOL,CARDIFF CF1 1XL,S GLAM,WALES

来源：

JOURNAL OF APPLIED BACTERIOLOGY | 1992年 / 72卷 / 04期

关键词：

D O I：

10.1111/j.1365-2672.1992.tb01844.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The effects of chlorhexidine diacetate (CHA) on Candida albicans, C. glabrata and wild-type and mannan, and permeability mutants of Saccharomyces cerevisiae have been studied. A CHA concentration of 10-mu-g/ml had little lethal activity against the Candida strains, but was more effective against S. cerevisiae. Concentrations of 100 and especially 1000-mu-g/ml brought about a much more rapid death of cells. 2-Mercaptoethanol enhanced the activity of CHA to some extent. Some of the mutant strains of S. cerevisiae were rather more sensitive than the wild-type strain. The age of cultures of C. albicans and C. glabrata influenced their response to CHA.

引用

页码：335 / 340

页数：6

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