SIMPLE METHODS FOR THE QUALITATIVE IDENTIFICATION AND QUANTITATIVE-DETERMINATION OF MACROLIDE ANTIBIOTICS

被引:27
作者
DANIELSON, ND
HOLEMAN, JA
BRISTOL, DC
KIRZNER, DH
机构
[1] Department of Chemistry, Miami University, Oxford
关键词
ERYTHROMYCIN; OLEANDOMYCIN; TROLEANDOMYCIN; TYLOSIN; SPIRAMYCIN; PYROLYSIS GAS CHROMATOGRAPHY; SPECTROPHOTOMETRY;
D O I
10.1016/0731-7085(93)80132-K
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Pyrolysis-gas chromatography is shown to be a rapid straightforward method for the qualitative differentiation of the macrolide antibiotics erythromycin, oleandomycin, troleandomycin, spiramycin and tylosin. Organic salts do not interfere and identification of erythromycin and troleandomycin in commercial products is viable. Spectrophotometric quantitation of these same five antibiotics after reaction with concentrated sulphuric acid is studied at about 470 nm. Reaction conditions such as acid concentration, time and temperature are provided. The sugar moieties of the antibiotics are proposed as the reactive sites. Detection limits are about 0.2-1.0 ng ml-1 and analysis of pharmaceutical products should be possible.
引用
收藏
页码:121 / 130
页数:10
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