CYTOKERATIN 19 FRAGMENTS - A NEW MARKER FOR NON-SMALL-CELL LUNG-CANCER

被引：37

作者：

STIEBER, P

BODENMULLER, H

BANAUCH, D

HASHOLZNER, U

DESSAUER, A

OFENLOCHHAHNLE, B

JAWOREK, D

FATEHMOGHADAM, A

机构：

[1] BOEHRINGER MANNHEIM GMBH,RES CTR TUTZING,BAHNHOFSTR 9-15,W-8132 TUTZING,GERMANY

[2] UNIV MUNICH,KLINIKUM GROSSHADERN,INST KLIN CHEM,W-8000 MUNICH 70,GERMANY

来源：

CLINICAL BIOCHEMISTRY | 1993年 / 26卷 / 04期

关键词：

CYFRA; 21-1; TUMOR MARKER; LUNG CANCER; CYTOKERATIN;

D O I：

10.1016/0009-9120(93)90129-T

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

We developed a new and automated assay for the detection of lung cancer associated cytokeratin 19 fragments in patients' sera/plasma. This new tumour marker assay CYFRA 21-1 was evaluated in technical and clinical studies using the multibatch analysers ES 300 and ES 600 from Boehringer Mannheim GmbH. The analytical performance was shown to be excellent. The clinical data from 2,037 patients demonstrate that for non-small-cell lung carcinoma CYFRA 21-1 has a higher diagnostic sensitivity compared to the established markers. Mainly for squamous cell carcinoma CYFRA 21-1 was superior (60%) to CEA (18%) or SCC (31%).

引用

页码：301 / 304

页数：4