ENANTIOMER SEPARATION OF 2-ARYLPROPIONIC ACIDS ON AN ERGOT ALKALOID-BASED STATIONARY-PHASE MICROBORE COLUMN APPLICATION

被引：22

作者：

CASTELLANI, L ^{[1
]}

FLIEGER, M ^{[1
]}

SINIBALDI, M ^{[1
]}

机构：

[1] ACAD SCI CZECH REPUBL,INST MICROBIOL,CR-14220 PRAGUE 4,CZECH REPUBLIC

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1994年 / 17卷 / 17期

关键词：

D O I：

10.1080/10826079408013986

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The separation of enantiomers of underivatized ketoprofen, as well as a number of other non-steroidal anti-inflammatory drugs, was studied by high performance liquid chromatography using a recently developed chiral stationary phase packed in a microbore column. Electrostatic and pi-pi interactions are assumed to control the retention of the analytes. The enantioselectivity remains constant in a wide range of organic modifier concentration, and is restricted to a pH window ranging from 2.5 to 5.0.

引用

页码：3695 / 3703

页数：9

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