ACUTE AND CHRONIC BEHAVIORAL SEQUELAE RESULTING FROM INTRASTRIATAL INJECTION OF AN NMDA AGONIST

被引：7

作者：

BLACK, MD

CROSSMAN, AR

HAYES, AG

ELLIOTT, PJ

机构：

[1] UNIV MANCHESTER,DEPT EXPTL NEUROL,MANCHESTER,LANCS,ENGLAND

[2] GLAXO GRP RES LTD,DEPT NEUROPHARMACOL,WARE,HERTS,ENGLAND

[3] ALKERMES,CAMBRIDGE,MA 02139

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1994年 / 48卷 / 02期

关键词：

NMDA; HUNTINGTONS DISEASE; BASAL GANGLIA; ROTATION; OPEN-FIELD BEHAVIORS; LESIONS;

D O I：

10.1016/0091-3057(94)90550-9

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Unilateral and bilateral injections of cis-2,4-methanoglutamate, a potent and selective NMDA agonist, were made into the striatum of rats. Unilateral injections elicited MK-801-sensitive dose-related increases in contralateral turning, beginning 10-15 min after injection. Bilateral injections elicited typical seizure-like behaviours commencing approximately 80 min postinjection. Forty-eight hours after unilateral injection, and presumably after lesion development, no spontaneous preference for turning was seen. Upon challenge with apomorphine (1 mg/kg SC), ipsilateral turning lasting approximately 60 min was seen. Correlates are drawn between this model and some of the features of Huntington's disease.

引用

页码：441 / 446

页数：6

共 32 条

[1] ABNORMALITIES OF STRIATAL PROJECTION NEURONS AND N-METHYL-D-ASPARTATE RECEPTORS IN PRESYMPTOMATIC HUNTINGTONS-DISEASE [J].