POSTEXTRASYSTOLIC TRANSIENT CONTRACTILE ALTERNANS IN CANINE HEARTS

被引：21

作者：

ARAKI, J ^{[1
]}

TAKAKI, M ^{[1
]}

MATSUSHITA, T ^{[1
]}

MATSUBARA, H ^{[1
]}

SUGA, H ^{[1
]}

机构：

[1] OKAYAMA UNIV,SCH MED,DEPT PHYSIOL 2,2 SHIKATA CHO,OKAYAMA 700,JAPAN

来源：

HEART AND VESSELS | 1994年 / 9卷 / 05期

关键词：

ARRHYTHMIA; EXTRASYSTOLE; PREMATURE BEAT; POTENTIATION; COMPENSATORY PAUSE; COUPLING INTERVAL;

D O I：

10.1007/BF01745104

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We found that postextrasystolic potentiated contractility after a spontaneous extrasystole most frequently decayed as a transient alternans over several beats in excised, cross-circulated, atrially paced canine hearts. This type of heart preparation, which we have been using consistently in mechanoenergetic studies, had normal coronary blood perfusion pressure as well as flow and mechanoenergic performance. Spontaneous atrial and ventricular extrasysoles occurred occasionally in every heart. Arrhythmic changes in left ventricular (LV) pressure at a fixed volume reflected corresponding changes in contractility. We analyzed nearly 3,600 cases of postextrasystolic potentiation in 68 hearts; 84% decayed as transient alternans 6% decayed exponentially, and 10% belonged to neither type. We found that a postextrasystolic compensatory pause always preceded the transient alternans after either an atrial or ventricular extrasystole at any constant atrial pacing rate (85-188 beats/min). The decay was either exponential or nonalternating when the pause did not exist after an atrial extrasystole during occasional pacing failure. Therefore, the compensatory pause after either an atrial or ventricular extrasystole seems essential for the postextrasystolic transient alternans of LV contractility in the type of canine heart preparation we have been using.

引用

页码：241 / 248

页数：8

共 34 条

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