PROSTAGLANDINS AS REGULATORS IN CELLULAR IMMUNITY

被引：47

作者：

BRAY, MA

GORDON, D

MORLEY, J

机构：

[1] Department of Clinical Pharmacology, Cardiothoracic Institute, London, SW3 6HP, Fulham Road

来源：

PROSTAGLANDINS AND MEDICINE | 1978年 / 1卷 / 03期

关键词：

D O I：

10.1016/0161-4630(78)90105-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Guinea-pig peritoneal macrophages have been shown to generate substantial concentrations of E-type prostaglandins during culture in vitro. Partially purified lymphokine preparations stimulate PGE production y macrophages. Exogenous PGEl and PGE2 are potent inhibitors of lymphocyte activation and secretion of lymphokines causing lymphocyte mitogenesis and macrophage migration inhibition. Also indomethacin augments the secretion of these lymphokines in vitro. It is therefore suggested that production of PGE by macrophages provides a physiological mechanism for the regulation of lymphocyte activation in reactions of delayed hypersensitivity. © 1978.

引用

页码：183 / 199

页数：17

共 39 条

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