STRUCTURE OF FOOT-AND-MOUTH-DISEASE VIRUS CAPSID

被引:39
作者
VASQUEZ, C
DENOYA, CD
LATORRE, JL
PALMA, EL
机构
[1] Centro de Virologia Animal
关键词
D O I
10.1016/0042-6822(79)90387-8
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Electron microscope images of negative-stained particles of FMDV have been analyzed. The viral capsid appeared to be a pliant structure composed of monomers having an average width of about 2.5 nm and a length of 4 nm. Upon capsid disruption, a sequential and nonrandom detachment of skullcaps was observed. These skullcaps are presumably clusters of monomers, and they could be similar to those predicted for the 13-14 S subunits described for other picornaviruses. If this were the case, each FMDV capsid would be constituted by twelve skullcaps, making a total of 180 monomeric units for the outer part of the protein shell. However, the FMDV skullcap, compared with other picornavirus subunits, has a lower sedimentation coefficient (12 S) and shows high stability upon treatment with urea without production of the 4-5 S component characteristic of other related viruses. © 1979.
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页码:195 / 200
页数:6
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