SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING A CARBOXYL GROUP AT EITHER THEIR 5' END OR THEIR 3' END AND THEIR SUBSEQUENT DERIVATIZATION BY AN INTERCALATING AGENT

被引：24

作者：

GOTTIKH, M ^{[1
]}

ASSELINE, U ^{[1
]}

THUONG, NT ^{[1
]}

机构：

[1] MV LOMONOSOV STATE UNIV,AN BELOZERSKY LAB,MOSCOW 117234,USSR

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 46期

关键词：

D O I：

10.1016/S0040-4039(00)97139-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The attachment of an unprotected aminoacid either at the 5′ end of an oligonucleotide via a carbamate linkage or at the 3′ end via a phosphoramidate bond leads to modified oligonu- cleotides containing carboxyl group via a linker. These carboxyl groups can then specifically react with the primary amino group of daunomycin in the presence of carbodiimide. © 1990.

引用

页码：6657 / 6660

页数：4

共 7 条

[1] SOLID-PHASE SYNTHESIS OF MODIFIED OLIGODEOXYRIBONUCLEOTIDES WITH AN ACRIDINE DERIVATIVE OR A THIOPHOSPHATE GROUP AT THEIR 3'END
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[2] DEOXYNUCLEOSIDE PHOSPHORAMIDITES - A NEW CLASS OF KEY INTERMEDIATES FOR DEOXYPOLYNUCLEOTIDE SYNTHESIS
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[4] MODIFICATION OF OLIGO (POLY) NUCLEOTIDE PHOSPHOMONOESTER GROUPS IN AQUEOUS-SOLUTIONS
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[5] KNORRE DG, 1989, TOPICS MOL STRUCTURE, P172
[6] THUONG NT, 1989, TOPICS MOL STRUCTURA, V12, P25
[7] ZHABORAVA Z, 1988, BIOCHIMIE, V70, P1323

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