DIETHYLDITHIOCARBAMATE AND DITHIZONE AUGMENT THE TOXICITY OF KAINIC ACID

被引：32

作者：

MITCHELL, CL ^{[1
]}

BARNES, MI ^{[1
]}

GRIMES, LM ^{[1
]}

机构：

[1] UNIV N CAROLINA,CURRICULUM TOXICOL,CHAPEL HILL,NC 27514

来源：

BRAIN RESEARCH | 1990年 / 506卷 / 02期

关键词：

Diethyldithiocarbamate; Dithizone; Heavy metal chelator; Intravital stain; Kainic acid; Seizure; Wet dog shake; Zinc;

D O I：

10.1016/0006-8993(90)91273-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Male Fischer-344 rats were injected i.p. with diethyldithiocarbamate or dithizone 15 min after kainic acid (KA), s.c. Diethyldithiocarbamate and dithizone reduced both the number of wer dog shakes and the latency to onset of seizures induced by KA. Moreover, they increased the severity of seizures. These compounds may be useful tools for investigating the role of zinc in central nervous system excitatory transmission and/or convulsive phenomena. © 1990.

引用

页码：327 / 330

页数：4

共 32 条

[1] SELECTIVE RELEASE OF ENDOGENOUS ZINC FROM THE HIPPOCAMPAL MOSSY FIBERS INSITU
ANIKSZTEJN, L
CHARTON, G
BENARI, Y
[J]. BRAIN RESEARCH, 1987, 404 (1-2) : 58 - 64
[2] [Anonymous], 1956, NONPARAMETRIC STAT B
[3] ASSOF SY, 1984, NATURE, V308, P734
[4] BERTINO R, 1984, Bollettino Societa Italiana Biologia Sperimentale, V60, P1721
[5] CHARTON G, 1985, EXP BRAIN RES, V58, P202
[6] CHUNG SH, 1986, EXCITATORY AMINO ACI, P545
[7] CRAWFORD IL, 1975, J ORTHOMOL MED, V4, P39
[8] PERSISTENT FUNCTION OF MOSSY FIBER SYNAPSES AFTER METAL CHELATION WITH DEDTC (ANTABUSE)
DANSCHER, G
SHIPLEY, MT
ANDERSEN, P
[J]. BRAIN RESEARCH, 1975, 85 (03) : 522 - 526
[9] EFFECT OF DIETHYLDITHIOCARBAMATE (DEDTC) ON SULFIDE SILVER STAINED BOUTONS - REVERSIBLE BLOCKING OF TIMMS SULFIDE SILVER STAIN FOR HEAVY-METALS IN DEDTC TREATED RATS (LIGHT-MICROSCOPY)
DANSCHER, G
HAUG, FMS
FREDENS, K
[J]. EXPERIMENTAL BRAIN RESEARCH, 1973, 16 (05) : 521 - 532
[10] REDUCED EXCITATORY EFFECT OF KAINIC ACID ON RAT CA3 HIPPOCAMPAL PYRAMIDAL NEURONS FOLLOWING DESTRUCTION OF THE MOSSY PROJECTION WITH COLCHICINE
DEMONTIGNY, C
WEISS, M
OUELLETTE, J
[J]. EXPERIMENTAL BRAIN RESEARCH, 1987, 65 (03) : 605 - 613

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