CYSTICERCOSIS VACCINE - CROSS PROTECTING IMMUNITY WITH T-SOLIUM ANTIGENS AGAINST EXPERIMENTAL MURINE T-CRASSICEPS CYSTICERCOSIS

被引：74

作者：

SCIUTTO, E

FRAGOSO, G

TRUEBA, L

LEMUS, D

MONTOYA, RM

DIAZ, ML

GOVEZENSKY, T

LOMELI, C

TAPIA, G

LARRALDE, C

机构：

[1] NATL AUTONOMOUS UNIV MEXICO, INST INVEST BIOMED, AP 70228, MEXICO CITY 04510, DF, MEXICO

[2] SECRETARIA AGR & RECURSOS HIDRAULICOS, INST INVEST PECUARIAS, MEXICO CITY, DF, MEXICO

来源：

PARASITE IMMUNOLOGY | 1990年 / 12卷 / 06期

关键词：

cysticercosis vaccine; T. solium and T. crassiceps cross immunity;

D O I：

10.1111/j.1365-3024.1990.tb00997.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Summary Vaccination of mice with an antigen extract from Taenia solium cysticerci induced protection against challenge with T. crassiceps cysticerci as successfully as did antigen extracts from T. crassiceps. Vaccination was more effective in male than in female mice and in the resistant strain (BALB/B) more so than in the susceptible strain (BALB/c). While only the resistant strain was completely protected by vaccination, the parasite load of the susceptible strain was significantly reduced by vaccination. Cross immunity between the human and murine parasites establishes murine T. crassiceps cysticercosis as a convenient laboratory model in which to test promising T. solium antigens aimed at vaccine development against T. solium cysticercosis. Further, results point to strong interactions of the immune system with sexual and histocompatibility factors in the host's dealing with cysticercosis. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：687 / 696

页数：10

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