ELECTRICALLY STIMULATED RAPID GENE-EXPRESSION IN THE BRAIN - ORNITHINE DECARBOXYLASE AND C-FOS

被引:49
作者
ZAWIA, NH
BONDY, SC
机构
[1] UNIV CALIF IRVINE,DEPT COMMUNITY & ENVIRONM MED,IRVINE,CA 92717
[2] UNIV CALIF IRVINE,SO OCCUPAT HLTH CTR,IRVINE,CA 92717
[3] UNIV CALIF IRVINE,DEPT PHARMACOL,IRVINE,CA 92717
来源
MOLECULAR BRAIN RESEARCH | 1990年 / 7卷 / 03期
关键词
Adaptation; c-fos; Electroconvulsive shock; Gene expression; mRNA; Neocortex; Ornithine decarboxylase;
D O I
10.1016/0169-328X(90)90034-B
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A single electroconvulsive shock (ECS) resulted in a major induction of cerebral ornithine decarboxylase (ODC) mRNA and a rapid and transient elevation of ODC enzyme activity. The proto-oncogene c-fos was also transiently induced under the same conditions. Following a rapid rise in mRNA levels, the messages for these proteins take different courses. The c-fos mRNA fell to below control levels by 1 h, while the ODC mRNA remained elevated beyond 24 h. The ECS-induced elevation of ODC enzyme activity was not abolished by adrenalectomy but was attenuated significantly by the anti-convulsant MK-801. These results imply that the induction of cerebral ODC may be neuronal activity dependent, and suggest that the ODC/polyamine system may be linked to the proposed third messenger cascade, involving c-fos, which couples cell stimulation to gene expression, resulting in long-term adaptive responses. © 1990.
引用
收藏
页码:243 / 247
页数:5
相关论文
共 30 条
  • [1] REGIONAL VARIATION IN THE RESPONSE OF CEREBRAL ORNITHINE DECARBOXYLASE TO ELECTROCONVULSIVE SHOCK
    BONDY, SC
    MITCHELL, CL
    RAHMAAN, S
    MASON, G
    [J]. NEUROCHEMICAL PATHOLOGY, 1987, 7 (02): : 129 - 141
  • [2] THE C-FOS PROTEIN INTERACTS WITH C-JUN/AP-1 TO STIMULATE TRANSCRIPTION OF AP-1 RESPONSIVE GENES
    CHIU, R
    BOYLE, WJ
    MEEK, J
    SMEAL, T
    HUNTER, T
    KARIN, M
    [J]. CELL, 1988, 54 (04) : 541 - 552
  • [3] EVIDENCE FOR THE EXISTENCE OF ORNITHINE DECARBOXYLASE-IMMUNOREACTIVE NEURONS IN THE RAT-BRAIN
    CINTRA, A
    FUXE, K
    AGNATI, LF
    PERSSON, L
    HARFSTRAND, A
    ZOLI, M
    ENEROTH, P
    ZINI, I
    [J]. NEUROSCIENCE LETTERS, 1987, 76 (03) : 269 - 274
  • [4] NUMBER AND EVOLUTIONARY CONSERVATION OF ALPHA-TUBULIN AND BETA-TUBULIN AND CYTOPLASMIC BETA-ACTIN AND GAMMA-ACTIN GENES USING SPECIFIC CLONED CDNA PROBES
    CLEVELAND, DW
    LOPATA, MA
    MACDONALD, RJ
    COWAN, NJ
    RUTTER, WJ
    KIRSCHNER, MW
    [J]. CELL, 1980, 20 (01) : 95 - 105
  • [5] MEMORIES OF FOS
    CURRAN, T
    MORGAN, JI
    [J]. BIOESSAYS, 1987, 7 (06) : 255 - 258
  • [6] DAM AM, 1982, ACTA NEUROL SCAND, V66, P606
  • [7] MOUSE-BRAIN C-FOS MESSENGER-RNA DISTRIBUTION FOLLOWING A SINGLE ELECTROCONVULSIVE SHOCK
    DAVAL, JL
    NAKAJIMA, T
    GLEITER, CH
    POST, RM
    MARANGOS, PJ
    [J]. JOURNAL OF NEUROCHEMISTRY, 1989, 52 (06) : 1954 - 1957
  • [8] INDUCTION OF BRAIN ORNITHINE DECARBOXYLASE DURING RECOVERY FROM METABOLIC, MECHANICAL, THERMAL, OR CHEMICAL INJURY
    DIENEL, GA
    CRUZ, NF
    [J]. JOURNAL OF NEUROCHEMISTRY, 1984, 42 (04) : 1053 - 1061
  • [9] FOURNEY R, 1988, FOCUS, V10, P55
  • [10] THE FOS COMPLEX AND FOS-RELATED ANTIGENS RECOGNIZE SEQUENCE ELEMENTS THAT CONTAIN AP-1 BINDING-SITES
    FRANZA, BR
    RAUSCHER, FJ
    JOSEPHS, SF
    CURRAN, T
    [J]. SCIENCE, 1988, 239 (4844) : 1150 - 1153