THE EFFECT OF TYPICAL AND ATYPICAL ANTIPSYCHOTIC-DRUGS ON THE STIMULATION OF PHOSPHOINOSITIDE HYDROLYSIS PRODUCED BY THE 5-HT3 RECEPTOR AGONIST 2-METHYL-SEROTONIN

被引：14

作者：

EDWARDS, E ^{[1
]}

ASHBY, CR ^{[1
]}

WANG, RY ^{[1
]}

机构：

[1] SUNY STONY BROOK,HLTH SCI CTR,DEPT PSYCHIAT & BEHAV SCI,STONY BROOK,NY 11794

来源：

BRAIN RESEARCH | 1991年 / 545卷 / 1-2期

关键词：

SEROTONIN; FRONTO-CINGULATE (PREFRONTAL) CORTEX; ENTORHINAL CORTEX; SEROTONIN-3; RECEPTOR; SEROTONIN-3 RECEPTOR ANTAGONIST; PHOSPHOINOSITIDE HYDROLYSIS; ANTIPSYCHOTIC DRUG;

D O I：

10.1016/0006-8993(91)91296-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The atypical antipsychotic drug clozapine (CLOZ) and a structurally related compound RMI 81,582 (RMI) dose-dependently inhibited the stimulation of phosphoinositide hydrolysis induced by the 5-HT3 receptor agonist 2-methyl-serotonin in the rat fronto-cingulate and entorhinal cortices. The antagonism of 2-methyl-serotonin's stimulation of phosphoinositide hydrolysis by CLOZ and RMI was comparable to that observed with 5-HT3 antagonists such as granisetron, ondansetron, ICS 205-930 and zacopride. By contrast, the typical antipsychotic drugs haloperidol (HAL) and chlorpromazine (CPZ) did not antagonize the stimulation of phosphoinositide hydrolysis induced by 2-methyl-serotonin. The 5-HT3 receptor antagonizing effect of CLOZ and RMI may contribute to the 'atypical' pharmacological profile of these antipsychotic drugs.

引用

页码：276 / 278

页数：3

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