SYNTHESIS OF PYRIDO[2,3-D]PYRIMIDINES IN THE REACTION OF 6-AMINO-2,3-DIHYDRO-2-THIOXO-4(1H)-PYRIMIDINONE WITH CHALCONES

被引：57

作者：

QUIROGA, J

INSUASTY, B

SANCHEZ, A

NOGUERAS, M

MEIER, H

机构：

[1] UNIV VALLE,DEPT CHEM,CALI,COLOMBIA

[2] UNIV GRANADA,COL UNIV JAEN,DEPT ORGAN CHEM,E-23071 JAEN,SPAIN

[3] UNIV MAINZ,INST ORGAN CHEM,W-6500 MAINZ,GERMANY

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1992年 / 29卷 / 05期

关键词：

D O I：

10.1002/jhet.5570290502

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

6-Amino-2,3-dihydro-2-thioxo-4(1H)-pyrimidinone (1) reacts in boiling DMF with alpha,beta-unsaturated ketones 2 yielding the pyrido[2,3-d]pyrimidine systems 5 and 6, respectively. The orientation in the addition process can be determined by nmr measurements, especially by NOE difference spectroscopy. The products do not correspond to a normal Skraup or Doebner-v. Miller synthesis.

引用

页码：1045 / 1048

页数：4

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