FOLIC-ACID IN SERUM AND CEREBROSPINAL-FLUID OF CHRONIC-ALCOHOLICS AND METHAMPHETAMINE ADDICTS

被引：7

作者：

NAKAZAWA, Y ^{[1
]}

YOKOYAMA, T ^{[1
]}

KURAUCHI, H ^{[1
]}

UEDA, S ^{[1
]}

SAKAMOTO, T ^{[1
]}

IMATOH, N ^{[1
]}

EZAKI, E ^{[1
]}

机构：

[1] KAISEI HOSP, FUKUOKA, JAPAN

来源：

DRUG AND ALCOHOL DEPENDENCE | 1981年 / 7卷 / 02期

关键词：

D O I：

10.1016/0376-8716(81)90033-8

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

The folic acid (FA) levels in serum and CSF of 39 chronic alcoholics, 15 methamphetamine addicts and 18 control subjects were determined using the technique of Lactobacillus casei assay. Twelve of the 39 alcoholics developed delirium tremens (DT) after determination of the FA level. The serum FA level of the alcoholics with DT was significantly < that of the controls and showed a tendency to be < in the alcoholics without DT. The CSF FA of the DT group was significantly < that of the control group and of the alcoholics without DT. In the methamphetamine addicts, although the serum FA was significantly < that of the controls, the CSF FA remained unchanged. All the methamphetamine addicts demonstrated psychological dependence and tolerance development as did the alcoholics, but they did not show any physical dependence. From these results, a mechanism underlying the development of symptoms of physical dependence such as DT was discussed in relation to the CSF FA.

引用

页码：193 / 199

页数：7

共 19 条

[1] BRAIN FUNCTION OF INFANTS FED ON MILK FROM MOTHERS WITH LOW SERUM FOLATE LEVELS [J].