A COMBINED ADJUVANT AND CARRIER SYSTEM FOR ENHANCING SYNTHETIC PEPTIDES IMMUNOGENICITY UTILIZING LIPIDIC AMINO-ACIDS

被引：72

作者：

TOTH, I

DANTON, M

FLINN, N

GIBBONS, WA

机构：

[1] The School of Pharmacy, University of London, 23-39 Brunswick Sq.

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(00)79265-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Lipid-Core-Peptide (LCP) system which incorporates lipidic amino acids to the polylysine system to enhance lipophilicity and membrane binding effects of a potential peptide-vaccine is an excellent means for enhancing antigenicity. Different spacer-(lipidic amino acid)n-(L-Lys)m systems were synthesised on solid phase, with a fully automated procedure, using BOC strategy.

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页码：3925 / 3928

页数：4

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