CHANGES IN RELIABILITY OF SYNAPTIC FUNCTION AS A MECHANISM FOR PLASTICITY

被引：322

作者：

STEVENS, CF

WANG, YY

机构：

[1] Laboratory for Molecular Neurobiology, Howard Hughes Medical Institute, Salk Institute, San Diego, CA 92110

来源：

NATURE | 1994年 / 371卷 / 6499期

关键词：

D O I：

10.1038/371704a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

SYNAPTIC transmission in the hippocampus is rather unreliable, with many presynaptic action potentials failing to release neurotransmitter(1-4). How is this unreliability affected by the alterations in synaptic strength seen in long-term potentiation (LTP)(5) and long-term depression(6,7) (LTD)? We find that LTP increases synaptic reliability, and LTD decreases it, both without a change in the size of those postsynaptic currents that do occur. Thus LTD is a functional inverse of LTP.

引用

页码：704 / 707

页数：4

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