REVERSE-TRANSCRIPTASE MUTATIONS IN SEQUENTIAL HIV-1 ISOLATES IN A PATIENT WITH AIDS

被引：17

作者：

GURUSINGHE, AD

LAND, SA

BIRCH, C

MCGAVIN, C

HOOKER, DJ

TACHEDJIAN, G

DOHERTY, R

DEACON, NJ

机构：

[1] MACFARLANE BURNET CTR MED RES,VIRUS INTERACT LAB,FAIRFIELD,VIC 3078,AUSTRALIA

[2] NATL CTR HIV VIROL RES,AIDS MOLEC BIOL LAB,FAIRFIELD,VIC,AUSTRALIA

[3] NATL CTR HIV VIROL RES,ANTIVIRALS RES LAB,FAIRFIELD,VIC,AUSTRALIA

[4] FAIRFIELD HOSP,VICTORIAN STATE HIV ISOLAT LAB,FAIRFIELD,VIC 3078,AUSTRALIA

来源：

JOURNAL OF MEDICAL VIROLOGY | 1995年 / 46卷 / 03期

关键词：

HIV-1; AZT; RESISTANCE; REVERSE TRANSCRIPTASE; MUTATIONS;

D O I：

10.1002/jmv.1890460312

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Sequential human immunodeficiency virus type 1 (HIV-1) isolates were obtained over a 29-month period from a person before, during, and after AZT therapy. DNA sequence analysis of polymerase chain-amplified reverse-transcriptase gene showed a gradual accumulation of mutations to peak resistance (IC50 2.13 mu M AZT) in association with mutations at codons 44, 210, and 369, as well as at 41, 67, 70, and 215. Eight months after cessation of AZT therapy, when an HIV-1 isolate from the patient was again sensitive to AZT, these mutations had all returned to the pretherapy sequence. (C) 1995 Wiley-Liss, Inc.

引用

页码：238 / 243

页数：6

共 22 条

[1] IMPROVEMENT OF PCR AMPLIFIED DNA SEQUENCING WITH THE AID OF DETERGENTS
BACHMANN, B
LUKE, W
HUNSMANN, G
[J]. NUCLEIC ACIDS RESEARCH, 1990, 18 (05) : 1309 - 1309
[2] ALTERED SENSITIVITY TO ANTIVIRAL DRUGS OF HERPES-SIMPLEX VIRUS ISOLATES FROM A PATIENT WITH THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME
BIRCH, CJ
TACHEDJIAN, G
DOHERTY, RR
HAYES, K
GUST, ID
[J]. JOURNAL OF INFECTIOUS DISEASES, 1990, 162 (03) : 731 - 734
[3] CLINICAL EFFECTS AND INVITRO STUDIES OF TRIFLUOROTHYMIDINE COMBINED WITH INTERFERON-ALPHA FOR TREATMENT OF DRUG-RESISTANT AND DRUG-SENSITIVE HERPES-SIMPLEX VIRUS-INFECTIONS
BIRCH, CJ
TYSSEN, DP
TACHEDJIAN, G
DOHERTY, R
HAYES, K
MIJCH, A
LUCAS, CR
[J]. JOURNAL OF INFECTIOUS DISEASES, 1992, 166 (01) : 108 - 112
[4] ORDERED APPEARANCE OF ZIDOVUDINE RESISTANCE MUTATIONS DURING TREATMENT OF 18 HUMAN IMMUNODEFICIENCY VIRUS-POSITIVE SUBJECTS
BOUCHER, CAB
OSULLIVAN, E
MULDER, JW
RAMAUTARSING, C
KELLAM, P
DARBY, G
LANGE, JMA
GOUDSMIT, J
LARDER, BA
[J]. JOURNAL OF INFECTIOUS DISEASES, 1992, 165 (01) : 105 - 110
[5] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 POL GENE-MUTATIONS IN AN AIDS PATIENT TREATED WITH MULTIPLE ANTIRETROVIRAL DRUGS
FITZGIBBON, JE
FARNHAM, AE
SPERBER, SJ
KIM, H
DUBIN, DT
[J]. JOURNAL OF VIROLOGY, 1993, 67 (12) : 7271 - 7275
[6] 5TH MUTATION IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE CONTRIBUTES TO THE DEVELOPMENT OF HIGH-LEVEL RESISTANCE TO ZIDOVUDINE
KELLAM, P
BOUCHER, CAB
LARDER, BA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (05) : 1934 - 1938
[7] ZIDOVUDINE TREATMENT RESULTS IN THE SELECTION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VARIANTS WHOSE GENOTYPES CONFER INCREASING LEVELS OF DRUG-RESISTANCE
KELLAM, P
BOUCHER, CAB
TIJNAGEL, JMGH
LARDER, BA
[J]. JOURNAL OF GENERAL VIROLOGY, 1994, 75 : 341 - 351
[8] KURITZKES DR, 1993, 1ST NAT C HUM RETR R, P55
[9] REVERSION FROM ZIDOVUDINE RESISTANCE TO SENSITIVITY ON CESSATION OF TREATMENT
LAND, S
MCGAVIN, K
BIRCH, C
LUCAS, R
[J]. LANCET, 1991, 338 (8770) : 830 - 831
[10] DECREASED INVITRO SUSCEPTIBILITY TO ZIDOVUDINE OF HIV ISOLATES OBTAINED FROM PATIENTS WITH AIDS
LAND, S
TRELOAR, G
MCPHEE, D
BIRCH, C
DOHERTY, R
COOPER, D
GUST, I
[J]. JOURNAL OF INFECTIOUS DISEASES, 1990, 161 (02) : 326 - 329

← 1 2 3 →