FRUCTOSAMINE IN OBESE NORMAL SUBJECTS AND TYPE-2 DIABETES

被引：15

作者：

ARDAWI, MSM

NASRAT, HAN

BAHNASSY, AA

机构：

[1] Department of Clinical Biochemistry, King Abdulaziz University Hospital and College of Medicine, King Abdulaziz University, Jeddah

[2] Department of Obstetrics and Gynaecology, King Abdulaziz University Hospital and College of Medicine, King Abdulaziz University, Jeddah

[3] Department of community Medicine, King Abdulaziz University Hospital and College of Medicine, King Abdulaziz University, Jeddah

来源：

DIABETIC MEDICINE | 1994年 / 11卷 / 01期

关键词：

FRUCTOSAMINE; DIABETES; OBESITY; GLYCEMIC CONTROL; GLYCATION;

D O I：

10.1111/j.1464-5491.1994.tb00229.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of various grades of obesity on serum fructosamine concentrations was studied in Type 2 diabetic (n = 105) and non-diabetic (n = 128) subjects. In obese diabetic and non-diabetic subjects (body mass index greater-than-or-equal-to 30 kg m-2), the concentration of fructosamine was markedly lower than that obtained for lean diabetic and non-diabetic subjects with similar glycaemic control. Stepwise multiple-regression analysis showed that fructosamine was associated with glycaemic control (as indicated by fasting plasma glucose and glycated haemoglobin), fasting triglycerides, and body mass index in both diabetic and non-diabetic subjects. In vitro studies showed marked decreases in both the extent of [C-14]-glucose incorporation into plasma proteins and fructosamine production by incubated sera of obese patients whether diabetic or non-diabetic, with obese subjects with body mass index > 40 kg m-2 exhibiting the greatest decrease. In conclusion, serum fructosamine concentrations are shown to decrease in obese diabetic and non-diabetic subjects with body mass index greater-than-or-equal-to 30 kg m-2 giving rise to the underestimation of glycaemic control as indicated by fructosamine measurement. A change in the glycation reaction itself may be partly responsible for such decrease.

引用

页码：50 / 56

页数：7

共 27 条

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