LOCALIZATION OF ANTIENDOMETRIAL ANTIBODY-BINDING IN WOMEN WITH ENDOMETRIOSIS USING A DOUBLE-LABELING IMMUNOHISTOCHEMICAL METHOD

被引：31

作者：

KENNEDY, SH ^{[1
]}

SARGENT, IL ^{[1
]}

STARKEY, PM ^{[1
]}

HICKS, BR ^{[1
]}

BARLOW, DH ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP,NUFFIELD DEPT OBSTET & GYNAECOL,OXFORD OX3 9DU,ENGLAND

来源：

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 1990年 / 97卷 / 08期

关键词：

D O I：

10.1111/j.1471-0528.1990.tb16236.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Summary. Anti‐endometrial antibody binding was localized using a double‐labelling immunohistochemical method on frozen sections of endometrium taken from a woman without pelvic disease. Serum from 40 women with endometriosis was tested and, as controls, serum samples from 20 adult males and 20 umbilical cords. The method allowed compensation for endogenous immunoglobulins in endometrium and accurate localization of anti‐endometrial antibody binding in the cytoplasm of the glandular epithelium. Significantly more women with endometriosis (14/40) were found to have anti‐endometrial antibodies than controls (1/40) (P< 0.001; χ2). There was no correlation between disease severity and the presence of anti‐endometrial antibodies or the intensity of staining. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：671 / 674

页数：4

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