HIGHLY SENSITIVE AND PRECISE RADIOENZYMATIC ASSAY FOR PLASMA EPINEPHRINE AND NOREPINEPHRINE

被引：21

作者：

MULLER, T ^{[1
]}

HOFSCHUSTER, E ^{[1
]}

KUSS, HJ ^{[1
]}

WELTER, D ^{[1
]}

机构：

[1] UNIV MUNICH,PSYCHIAT HOSP,DEPT NEUROCHEM,D-8000 MUNICH 2,FED REP GER

来源：

JOURNAL OF NEURAL TRANSMISSION | 1979年 / 45卷 / 03期

关键词：

Epinephrine; HPLC; norepinephrine; radioenzymatic assay;

D O I：

10.1007/BF01244410

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A modification of the procedures for simultaneous radiometric determinations of plasma epinephrine (E) and norepinephrine (NE) was developed. High performance liquid chromatography (HPLC) is excellently suited to separate the radioactive products of the enzymatic methylation of catecholamines. This time-saving procedure shows significant advantages as against the conventional method of isolating normetanephrine and metanephrine by thin layer chromatography. The high sensitivity (detection limit=1 pg), specifity, and good precision (cv=6%) of this assay are demonstrated. © 1979 Springer-Verlag.

引用

页码：219 / 225

页数：7

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