TRANSFORMING GROWTH-FACTORS TYPE-BETA AND DEXAMETHASONE ATTENUATE GROUP-II PHOSPHOLIPASE-A2 GENE-EXPRESSION BY INTERLEUKIN-1 AND FORSKOLIN IN RAT MESANGIAL CELLS

被引：43

作者：

MUHL, H

GEIGER, T

PIGNAT, W

MARKI, F

VANDENBOSCH, H

CERLETTI, N

COX, D

MCMASTER, G

VOSBECK, K

PFEILSCHIFTER, J

机构：

[1] UNIV BASEL,BIOCTR,DEPT PHARMACOL,KLINGELBERGSTR 70,CH-4056 BASEL,SWITZERLAND

[2] CIBA GEIGY AG,RES DEPT,DIV PHARMACEUT,CH-4002 BASEL,SWITZERLAND

[3] CTR BIOMEMBRANES & LIPID ENZYMOL,3584 CH UTRECHT,NETHERLANDS

来源：

FEBS LETTERS | 1992年 / 301卷 / 02期

关键词：

PHOSPHOLIPASE-A2; INTERLEUKIN-1; TRANSFORMING GROWTH FACTOR-BETA; DEXAMETHASONE; PHOSPHOLIPASE-A2 MESSENGER RNA; MESANGIAL CELL;

D O I：

10.1016/0014-5793(92)81245-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Treatment of rat mesangial cells with interleukin-1-beta (IL-1-beta) and forskolin induced, in a synergistic fashion, the expression of group II phospholipase A2 (PLA2) mRNA, with subsequent increased synthesis and secretion of PLA2. In contrast, interleukin-6 did not increase PLA2 mRNA levels of PLA2 activity. Transforming growth factor (TGF) beta(1), TGF-beta(2) and TGF-beta(3) equipotently attenuated the IL-1-beta- and forskolin-induced elevation of PLA2 mRNA, as well as PLA2 synthesis and secretion. The glucocorticoid dexamethasone only partially suppressed the IL-1-beta- and forskolin-induced elevation of PLA2 mRNA, but totally inhibited PLA2 synthesis and secretion.

引用

页码：190 / 194

页数：5

共 46 条

[1] LIPOCORTIN INHIBITION OF EXTRACELLULAR AND INTRACELLULAR PHOSPHOLIPASES-A2 IS SUBSTRATE CONCENTRATION DEPENDENT [J].