COMPUTERIZED LINEARIZATION TEST FOR TABLET DISSOLUTION KINETICS

被引：1

作者：

ARNAUD, P ^{[1
]}

ELKOUBI, C ^{[1
]}

RENAUX, C ^{[1
]}

LEHIR, A ^{[1
]}

机构：

[1] HOP PARIS,PHARM CENT,F-92033 NANTERRE,FRANCE

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 80卷 / 2-3期

关键词：

LINEARIZATION TEST; DISSOLUTION RATE; COMPUTERIZATION; TABLET;

D O I：

10.1016/0378-5173(92)90270-C

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have compared the linearization and computerized the dissolution rate of several commercially available tablets. Out of all the tested kinetic patterns, four have proved satisfactory (Higuchi, Hixson-Crowell, Kitazawa and Weibull). Considering the tablet characteristics, our research has been conducted according to the following criteria: tablets with low hardness and rapid release kinetics show Hixson-Crowell type linearization; tablets with a high rate of release of active substance display Higuchi-type linearization; tablets with high hardness but a short disintegration time show Kitazawa-type linearization, and finally, in the case of the rapid release of active substance in the dissolution medium, the curve was transformed into a straight line by using Weibull's equation.

引用

页码：129 / 133

页数：5

共 16 条

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