EFFECTS OF PRIOR EXPOSURE HISTORY ON CYTOCHROME-P4501A MESSENGER-RNA INDUCTION BY PCB CONGENER-77 IN ATLANTIC TOMCOD

被引：47

作者：

WIRGIN, II ^{[1
]}

KREAMER, GL ^{[1
]}

GRUNWALD, C ^{[1
]}

SQUIBB, K ^{[1
]}

GARTE, SJ ^{[1
]}

COURTENAY, S ^{[1
]}

机构：

[1] FISHERIES & OCEANS CANADA, MONCTON E1C 9B6, NB, CANADA

来源：

MARINE ENVIRONMENTAL RESEARCH | 1992年 / 34卷 / 1-4期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0141-1136(92)90091-Y

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Levels of P4501A mRNA in tomcod collected from the Miramichi River, Canda and the Hudson River, New York were measured by slot blot analyses after the fish had been depurated and ip. injected with Aroclor 1254, PCB congener 77, or PCB congener 105. Elevated expression of P4501A mRNA was observed in congener 77-treated Miramichi tomcod, whereas no induction was seen in the Hudson River fish. Tom cod from both rivers were induced by injection with beta-naphthoflavone. These results suggest that the prior exposure history of the Hudson River tomcod may have affected their non-inducibility by treatment with PCB congener 77.

引用

页码：103 / 108

页数：6

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