HIGH-DOSE VS LOW-DOSE IMMUNOGLOBULIN THERAPY IN THE LONG-TERM TREATMENT OF X-LINKED AGAMMAGLOBULINEMIA

被引:93
作者
LIESE, JG
WINTERGERST, U
TYMPNER, KD
BELOHRADSKY, BH
机构
[1] UNIV MUNICH,DEPT PEDIAT,DIV INFECT DIS & IMMUNOL,LINDWURMSTR 4,W-8000 MUNICH 2,GERMANY
[2] CITY HOSP,DEPT PEDIAT,HARLACHING,GERMANY
来源
AMERICAN JOURNAL OF DISEASES OF CHILDREN | 1992年 / 146卷 / 03期
关键词
D O I
10.1001/archpedi.1992.02160150075025
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The data of 29 patients with X-linked agammaglobulinemia, who received immunoglobulin replacement therapy between 1965 and 1990, were analyzed for dose-dependent long-term results concerning infectious complications. Patients who received high-dose intravenous immunoglobulin replacement (> 400 mg/kg every 3 weeks) showed a significant increase in trough serum IgG levels and a significant decrease in the incidence of pneumonias and the number of days spent in the hospital compared with patients receiving intravenous immunoglobulin low-dose (< 200 mg/kg every 3 weeks) or intramuscular immunoglobulin (< 100 mg/kg every 3 weeks) treatment. Improvements in therapeutic outcome were particularly evident when high-dose intravenous immunoglobulin replacement therapy was started before the age of 5 years. Bacterial meningitis, chronic pulmonary disease, and bronchiectasis occurred in the intramuscular immunoglobulin group but did not occur in either of the intravenous immunoglobulin groups. High-dose intravenous immunoglobulin therapy may have a positive impact on the clinical course and may prevent severe complications in patients with X-linked agammaglobulinemia.
引用
收藏
页码:335 / 339
页数:5
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