ABERRANT EXPRESSION OF THE TUMOR SUPPRESSOR GENE P53 IS VERY FREQUENT IN WILMS-TUMORS

被引：36

作者：

LEMOINE, NR ^{[1
]}

HUGHES, CM ^{[1
]}

COWELL, JK ^{[1
]}

机构：

[1] INST CHILD HLTH,DEPT HAEMATOL & ONCOL,ICRF ONCOL GRP,LONDON WC1N 1EH,ENGLAND

来源：

JOURNAL OF PATHOLOGY | 1992年 / 168卷 / 02期

关键词：

TUMOR SUPPRESSOR GENE; P53; WILMS TUMOR; IMMUNOHISTOCHEMISTRY;

D O I：

10.1002/path.1711680213

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A series of 34 Wilms' tumours have been analysed for abnormal expression of the tumour suppressor gene p53 using frozen section immunohistochemistry. All tumours showed immunoreactivity with at least one of the specific antibodies used (monoclonal antibody PAb240, polyclonal antibodies CM1 and JG8). Abnormalities of p53 expression are very frequent in this type of childhood tumour.

引用

页码：237 / 242

页数：6

共 35 条

[1]

BAKER SJ, 1990, CANCER RES, V50, P7717

[2]

BARTEK J, 1991, ONCOGENE, V6, P1699

[3]

BARTEK J, 1990, ONCOGENE, V5, P893

[4] ABNORMALITIES OF THE P53 TUMOR SUPPRESSOR GENE IN HUMAN PANCREATIC-CANCER [J].

BARTON, CM ;

STADDON, SL ;

HUGHES, CM ;

HALL, PA ;

OSULLIVAN, C ;

KLOPPEL, G ;

THEIS, B ;

RUSSELL, RCG ;

NEOPTOLEMOS, J ;

WILLIAMSON, RCN ;

LANE, DP ;

LEMOINE, NR .

BRITISH JOURNAL OF CANCER, 1991, 64 (06) :1076-1082

[5] WILMS TUMOR AND OTHER RENAL TUMORS OF CHILDHOOD - A SELECTIVE REVIEW FROM THE NATIONAL-WILMS-TUMOR-STUDY-PATHOLOGY-CENTER [J].

BECKWITH, JB .

HUMAN PATHOLOGY, 1983, 14 (06) :481-492

[6]

BOLANDE RP, 1972, PEDIATR PATHOL, V1, P227

[7] ISOLATION AND CHARACTERIZATION OF A ZINC FINGER POLYPEPTIDE GENE AT THE HUMAN CHROMOSOME-11 WILMS TUMOR LOCUS [J].

CALL, KM ;

GLASER, T ;

ITO, CY ;

BUCKLER, AJ ;

PELLETIER, J ;

HABER, DA ;

ROSE, EA ;

KRAL, A ;

YEGER, H ;

LEWIS, WH ;

JONES, C ;

HOUSMAN, DE .

CELL, 1990, 60 (03) :509-520

[8] P53 EXPRESSION IN BREAST-CANCER [J].

CATTORETTI, G ;

RILKE, F ;

ANDREOLA, S ;

DAMATO, L ;

DELIA, D .

INTERNATIONAL JOURNAL OF CANCER, 1988, 41 (02) :178-183

[9]

CHIBA I, 1990, ONCOGENE, V5, P1603

[10]

COWELL JK, 1991, ONCOGENE, V6, P595

← 1 2 3 4 →