PHYSICAL MAPPING OF 2000-KB OF THE MOUSE X-CHROMOSOME IN THE VICINITY OF THE XIST LOCUS

被引：14

作者：

COOPER, P

KEER, JT

MCCABE, VM

HAMVAS, RMJ

BROWN, SDM

RASTAN, S

BROCKDORFF, N

机构：

[1] MRC,CLIN RES CTR,COMPARAT BIOL SECT,WATFORD RD,HARROW HA1 3UJ,MIDDX,ENGLAND

[2] ST MARYS HOSP,SCH MED,DEPT BIOCHEM & MOLEC GENET,LONDON W2 1PG,ENGLAND

来源：

GENOMICS | 1993年 / 15卷 / 03期

关键词：

D O I：

10.1006/geno.1993.1109

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A physical map encompassing approximately 2.0 megabases (Mb) in the region of the mouse X-inactivation center has been constructed. The map extends from the Gjb-1 locus to the Xist locus and demonstrates the order of probes inseparable by genetic analysis. The deduced locus order is as follows: Gjb-1, Ccg-1, DXCrc171, Rps4, Phka, DXCrc177, DXCrc318, Xist. Detailed physical mapping in the region between the Phka and Xist loci indicates the position of CpG-rich islands associated with the 5‘ end of genes. The DXCrc177 and DXCrc318 loci, both defined by probes derived from linking clones, are associated with CpG-rich islands. The map provides a framework for the isolation of underlying sequences in the mouse X-inactivation center region. © 1993 by Academic Press, Inc.

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收藏

页码：570 / 575

页数：6

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