A 12-MONTH STUDY OF POLICOSANOL ORAL TOXICITY IN SPRAGUE-DAWLEY RATS

被引：55

作者：

ALEMAN, CL

MAS, R

HERNANDEZ, C

RODEIRO, I

CEREJIDO, E

NOA, M

CAPOTE, A

MENENDEZ, R

AMOR, A

FRAGA, V

SOTOLONGO, V

JIMENEZ, S

机构：

来源：

TOXICOLOGY LETTERS | 1994年 / 70卷 / 01期

关键词：

CHOLESTEROL-LOWERING DRUG; CHRONIC TOXICITY; HIGHER ALIPHATIC PRIMARY ALCOHOL; POLICOSANOL; SPRAGUE DAWLEY RAT;

D O I：

10.1016/0378-4274(94)90147-3

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Policosanol is a natural mixture of higher aliphatic primary alcohols. Oral toxicity of policosanol was evaluated in a 12-month study in which doses from 0.5 to 500 mg/kg were given orally to Sprague Dawley (SD) rats (20/sex/group) daily. There was no treatment-related toxicity. Thus, effects on body weight gain, food consumption, clinical observations, blood biochemistry, hematology, organ weight ratios and histopathological findings were similar in control and treated groups. This study supports the wide safety margin of policosanol when administered chronically.

引用

页码：77 / 87

页数：11