SYNTHESIS OF TRITIUM LABELED (+/-) 15-DEOXYSPERGUALIN TRIHYDROCHLORIDE

被引：4

作者：

DISCHINO, DD

COOK, DJ

SAULNIER, MG

TEPPER, MA

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Wallingford, Connecticut, 06492

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1993年 / 33卷 / 02期

关键词：

TRITIUM; (+/-) 15-DEOXYSPERGUALIN; DSG; IMMUNOSUPPRESSIVE;

D O I：

10.1002/jlcr.2580330208

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Tritium labeled (+/-) 15-deoxyspergualin, (+/-)-7-[(aminoiminomethyl) amino]-N-[2-[[4-[(3-aminopropyl)amino]butyl]amino]-1-hydroxy-2-oxoethyl][4,5-H-3(2)]heptanamide trihydrochloride was prepared from the acid catalyzed condensation of 7-guanidino[4,5-H-3(2)]heptanamide hydrochloride and glyoxyloylspermidine dihydrochloride in a total yield of 14.5%. The radiochemical purity was determined to be 91.1% and 95.4% on two different HPLC systems.

引用

页码：137 / 145

页数：9

共 10 条

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