STRUCTURE-ACTIVITY-RELATIONSHIPS OF ANESTHETIC ETHERS USING MOLECULAR CONNECTIVITY

被引：21

作者：

DIPAOLO, T ^{[1
]}

机构：

[1] MASSACHUSETTS COLL PHARM,BOSTON,MA 02115

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1978年 / 67卷 / 04期

关键词：

Anesthetics‐various aliphatic ethers; activity related to molecular connectivity indexes; Ethers; Various aliphaticanesthetic Activity and toxicity related to molecular connectivity indexes; Molecular connectivity indexes‐various aliphatic ethers; related to anesthetic activity and toxicity; Structure‐activity relationships—various aliphatic ethers; anesthetic activity and toxicity related to molecular connectivity indexex; Topological indexes‐molecular connectivity; various aliphatic ethers; Toxicity‐various aliphatic ethers; related to molecular connectivity indexes;

D O I：

10.1002/jps.2600670436

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure‐activity relationships in the anesthetic and toxic actions of 28 aliphatic ethers were simple functions of molecular connectivity indexes. These quantitative relationships are discussed briefly in the light of theories of the mechanism of action of general anesthetics. Copyright © 1978 Wiley‐Liss, Inc., A Wiley Company

引用

页码：564 / 566

页数：3

共 9 条

[1] VAN DER WAALS VOLUMES + RADII
BONDI, A
[J]. JOURNAL OF PHYSICAL CHEMISTRY, 1964, 68 (03) : 441 - +
[2] DIPAOLO T, 1977, MOL PHARMACOL, V13, P31
[3] RELATIONSHIP BETWEEN LIPOPHILIC CHARACTER AND ANESTHETIC ACTIVITY
GLAVE, WR
HANSCH, C
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1972, 61 (04) : 589 - &
[4] PARTITION-COEFFICIENTS AND STRUCTURE-ACTIVITY RELATIONSHIP OF ANESTHETIC-GASES
HANSCH, C
VITTORIA, A
SILIPO, C
JOW, PYC
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (06) : 546 - 548
[5] LIPOPHILIC CHARACTER AND BIOLOGICAL-ACTIVITY OF DRUGS .2. PARABOLIC CASE
HANSCH, C
CLAYTON, JM
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1973, 62 (01) : 1 - 21
[6] Kier L. B., 1976, MOLECULAR CONNECTIVI
[7] THE COMPARATIVE ANESTHETIC ACTIVITY OF THE ALIPHATIC ETHERS
MARSH, DF
LEAKE, CD
[J]. ANESTHESIOLOGY, 1950, 11 (04) : 455 - 463
[8] MILLER JC, 1975, MTP INT REV SCI BI 1, V12, P33
[9] PHYSICOCHEMICAL APPROACHES TO MODE OF ACTION OF GENERAL ANESTHETICS
MILLER, KW
SMITH, RA
SMITH, EB
PATON, WDM
[J]. ANESTHESIOLOGY, 1972, 36 (04) : 339 - +

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