ADENOSINE REDUCES CORTICAL NEURONAL INJURY INDUCED BY OXYGEN OR GLUCOSE DEPRIVATION INVITRO

被引：124

作者：

GOLDBERG, MP ^{[1
]}

MONYER, H ^{[1
]}

WEISS, JH ^{[1
]}

CHOI, DW ^{[1
]}

机构：

[1] STANFORD UNIV, MED CTR, SCH MED, DEPT NEUROL, STANFORD, CA 94305 USA

来源：

NEUROSCIENCE LETTERS | 1988年 / 89卷 / 03期

关键词：

D O I：

10.1016/0304-3940(88)90547-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The endogenous neuromodulatory purine, adenosine, substantially attenuated neuronal degeneration when added to dissociated cortical cell cultures acutely deprived of either oxygen or glucose. The protective effect of adenosine was concentration-dependent between 30 and 1000 .mu.M (EC50 about 100 .mu.M), and could be mimicked by the stable adenosine analogue N6-cyclohexyladenosine (10 .mu.M). Unlike postsynaptic glutamate receptor antagonists, which also block these forms of neuronal injury, adenosine did not alter the neurotoxicity of exogenously applied glutamate.

引用

页码：323 / 327

页数：5

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