CORTICOTROPIN-RELEASING FACTOR IS PRODUCED BY RAT LEYDIG-CELLS AND HAS A MAJOR LOCAL ANTIREPRODUCTIVE ROLE IN THE TESTIS

被引：91

作者：

FABBRI, A ^{[1
]}

TINAJERO, JC ^{[1
]}

DUFAU, ML ^{[1
]}

机构：

[1] NICHHD,ENDOCRINOL & REPROD RES BRANCH,BETHESDA,MD 20892

来源：

ENDOCRINOLOGY | 1990年 / 127卷 / 03期

关键词：

D O I：

10.1210/endo-127-3-1541

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cultured rat Leydig cells secreted considerable amounts of corticotropin-releasing factor (CRF). A major stimulus for Leydig cell-derived CRF was the trophic hormone LH/hCG, which released the peptlde in a dose dependent fashion. Incubation of Leydig cells with a CRF antagonist revealed tonic suppression of basal and hCG-stimulated testosterone production by endogenously produced CRF. These findings demonstrate that CRF acts via functional Leydig cell receptors to exert autocrine inhibitory actions on Leydig cell steroidogenesis. In the testis CRF acts as an antireproductive hormone and as a major local inhibitory regulator of Leydig cell function. © 1990 by The Endocrine Society.

引用

页码：1541 / 1543

页数：3

共 15 条

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