INVITRO ANTIMALARIAL ACTIVITY OF CRUDE EXTRACTS AND COMPOUNDS FROM ARTEMISIA-ABROTANUM L

被引：40

作者：

CUBUKCU, B

BRAY, DH

WARHURST, DC

MERICLI, AH

OZHATAY, N

SARIYAR, G

机构：

[1] UNIV LONDON LONDON SCH HYG & TROP MED, DEPT MED PARASITOL, LONDON WC1E 7HT, ENGLAND

[2] ISTANBUL UNIV, FAC PHARM, DEPT PHARMACOGNOSY, ISTANBUL, TURKEY

来源：

PHYTOTHERAPY RESEARCH | 1990年 / 4卷 / 05期

关键词：

1(S*)‐hydroxy‐α‐bisabololoxide A acetate; antimalarial activity; Artemisia abrotanum; isofraxidin;

D O I：

10.1002/ptr.2650040510

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Artemisia abrotanum L. (Compositae) is widely used in European herbal medicine for treatment of various ailments including fever. Crude extracts of this plant and some of their constituents were tested for antimalarial activity against Plasmodium falciparum in vitro using the technique of [3H]hypoxanthine incorporation. Two pure compounds, isofraxidin and a novel sesquiterpene, 1(S*)‐hydroxy‐α‐bisabololoxide A acetate were found to be active (IC50 values of 7.95 and 5.09 m̈g/mL, respectively). Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：203 / 204

页数：2

共 6 条

[1] QUANTITATIVE ASSESSMENT OF ANTI-MALARIAL ACTIVITY INVITRO BY A SEMIAUTOMATED MICRODILUTION TECHNIQUE [J].