ACQUIRED-RESISTANCE TO TICKS - EXPRESSION OF RESISTANCE BY C4-DEFICIENT GUINEA-PIGS

被引:74
作者
WIKEL, SK
机构
关键词
D O I
10.4269/ajtmh.1979.28.586
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Hartley and C4-deficient guinea pigs developed resistance to the ixodid tick, Dermacentor andersoni, after one infestation. Resistance was characterized by resistant animals of both groups allowing significantly fewer larvae (5-25%) to engorge during a second infestation than during an initial infestation (70-90%). Resistant animals in both groups developed cutaneous reactions at the site of tick attachment which were characterized by intraepidermal vesicles containing numerous basophils. In previous studies, tick-resistant Hartley guinea pigs deplete of complement by cobra venom factor were not able to express the resistance response and the skin reactions at the tick attachment sites were depleted of basophils. The use of cobra venom factor as an anti-complement probe could not distinguish the relative importance of the classical and/or alternate pathways of complement activation in the expression of tick resistance. The present study reports that C4-deficient guinea pigs, those with a total deficiency in the classical pathway of complement activation, but with an intact alternate pathway, can acquire and display tick resistance in a fashion similar to Hartley guinea pigs. This finding provides evidence that the alternate pathway of complement activation is important in the expression of tick resistance.
引用
收藏
页码:586 / 590
页数:5
相关论文
共 18 条
[1]  
ALLEN J R, 1973, International Journal for Parasitology, V3, P195, DOI 10.1016/0020-7519(73)90024-6
[2]  
Askenase P W, 1977, Prog Allergy, V23, P199, DOI 10.1159/000314242
[3]  
Bagnall B. G., 1975, Australian Veterinary Journal, V51, P159, DOI 10.1111/j.1751-0813.1975.tb09444.x
[4]  
Balashov YS, MISCELLANEOUS PUBLIC, V5, P159
[5]  
BOESE JL, 1974, J MED ENTOMOL, V11, P503
[6]  
COCHRANE CG, 1970, J IMMUNOL, V105, P55
[7]   GENETICALLY CONTROLLED TOTAL DEFICIENCY OF FOURTH COMPONENT OF COMPLEMENT IN GUINEA-PIG [J].
ELLMAN, L ;
GREEN, I ;
FRANK, M .
SCIENCE, 1970, 170 (3953) :74-&
[8]  
GARIN N S, 1972, Meditsinskaya Parazitologiya i Parazitarnye Bolezni, V41, P274
[9]  
GOTZE O, 1971, J EXP MED, V134, pS90
[10]  
HAYNES JD, 1978, J IMMUNOL, V120, P886