EFFECT OF TI(OI-PR)4 ON STEREOSELECTIVITY OF HALOCYCLIZATION OF 2-SUBSTITUTED 4-PENTENOIC ACID AND 4-PENTEN-1-OL

被引：19

作者：

KITAGAWA, O

SATO, T

TAGUCHI, T

机构：

[1] TOKYO COLL PHARM, 1432-1 HORINOUCHI, HACHIOJI, TOKYO 19203, JAPAN

[2] SHIONOGI & CO LTD, SHIONOGI RES LABS, FUKUSHIMA KU, OSAKA 553, JAPAN

来源：

CHEMISTRY LETTERS | 1991年 / 01期

关键词：

D O I：

10.1246/cl.1991.177

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Iodolactonization of 2-substituted (N-sulfonylamino, hydroxyl and hydroxymethyl groups)-4-pentenoic acid with NIS or I2 in the presence of Ti(Oi-Pr)4 gave the gamma-lactone with increased 1,3-cis-selectivity. Stereoselectivity in the haloetherification of 2-hydroxymethyl-4-penten-1-ol was reversed by the addition of Ti(Oi-Pr)4.

引用

页码：177 / 180

页数：4

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