METALATION OF DIAZINES .3. NEW SYNTHESIS OF ANALOGS OF TRIMETHOPRIM AND OF BACIMETHRIN

被引：32

作者：

PLE, N

TURCK, A

FIQUET, E

QUEGUINER, G

机构：

[1] INSA-IRCOF, Laboratoire de Chimie Organique Fine et Hétérocyclique, URA 1429, Mont St Aignan, 76131

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1991年 / 28卷 / 02期

关键词：

D O I：

10.1002/jhet.5570280213

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Chloro-2,6-dimethoxypyrimidine was lithiated by lithium 2,2,6,6-tetramethylpiperidide. The resulting lithio derivative was submitted to reaction with carbonyl derivatives, iodine and trimethyltin chloride. Synthesis of analogues of trimethoprim and of bacimetrin are reported.

引用

页码：283 / 287

页数：5

共 15 条

[1] A VERSATILE ROUTE TO POTENTIAL DIHYDROFOLATE-REDUCTASE INHIBITORS VIA THE HITHERTO UNKNOWN 6-BENZYL-2-(O-METHYL)URACILS - SYNTHESIS OF ISOTRIMETHOPRIM
BOTTA, M
ARTICO, M
MASSA, S
GAMBACORTA, A
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1989, 26 (03) : 883 - 884
[2] HECK RF, 1985, PALLADIUMREAGENTS OR
[3] KRESS TJ, 1979, J ORG CHEM, V4, P13
[4] LEDNICER D, 1984, ORGANIC CHEM DRUG SY, V1
[5] ONO A, 1987, SYNTHESIS-STUTTGART, P736
[6] SYNTHESIS OF SILYL AND STANNYL PYRIMIDINES
PARKANYI, C
CHO, NS
YOO, GS
[J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1988, 342 (01) : 1 - 7
[7] RADINOV R, 1986, SYNTHESIS-STUTTGART, P886
[8] RAUCKMAN BS, 1989, J MED CHEM, V32, P1827
[9] SELASSIE CD, 1989, J MED CHEM, V32, P1875
[10] PALLADIUM-CATALYZED COUPLING OF ORGANOTIN REAGENTS AND ALKENES WITH 4-IODOPYRIMIDINES
SOLBERG, J
UNDHEIM, K
[J]. ACTA CHEMICA SCANDINAVICA SERIES B-ORGANIC CHEMISTRY AND BIOCHEMISTRY, 1987, 41 (10): : 712 - 716

← 1 2 →