SYNTHESIS OF A NEW CLASS OF TC CHELATING-AGENTS - N2S2 MONOAMINEMONOAMIDE (MAMA) LIGANDS

被引：35

作者：

GUSTAVSON, LM ^{[1
]}

RAO, TN ^{[1
]}

JONES, DS ^{[1
]}

FRITZBERG, AR ^{[1
]}

SRINIVASAN, A ^{[1
]}

机构：

[1] NEORX CORP,410 W HARRISON,SEATTLE,WA 98119

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 40期

关键词：

D O I：

10.1016/0040-4039(91)80064-D

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel N2S2-monoamine amide (MAMA) bifunctional chelate was designed and synthesized for labeling of antibodies with Tc-99m. The chelate forms Tc complexes at a range of pH's and shows faster kinetics of complexation than N2S2-diamidedithiol (DADS) ligands. The MAMA chelate contains a carboxyl group for covalent attachment to amino groups on proteins.

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页码：5485 / 5488

页数：4

相关论文

共 12 条

[1] Synthesis of a Diaminedithiol Bifunctional Chelating Agent for Incorporation of Technetium-99m into Biomolecules [J].

Baidoo, Kwamena E. ;

Lever, Susan Z. .

BIOCONJUGATE CHEMISTRY, 1990, 1 (02) :132-137

[2]

EARY J, 1987, Journal of Nuclear Medicine, V28, P650

[3] APPROACHES TO RADIOLABELING OF ANTIBODIES FOR DIAGNOSIS AND THERAPY OF CANCER [J].

FRITZBERG, AR ;

BERNINGER, RW ;

HADLEY, SW ;

WESTER, DW .

PHARMACEUTICAL RESEARCH, 1988, 5 (06) :325-334

[4]

FRITZBERG AR, 1990, Patent No. 4897255

[5] SULFUR-CONTAINING POLYPEPTIDES .3. S -] NBENZOYL GROUP MIGRATION IN CYSTEINE DERIVATIVES [J].

HISKEY, RG ;

MIZOGUCH.T ;

INUI, T .

JOURNAL OF ORGANIC CHEMISTRY, 1966, 31 (04) :1192-&

[6] A CONVENIENT SYNTHESIS OF VICINAL DIAMINES [J].

JONES, DS ;

SRINIVASAN, A ;

KASINA, S ;

FRITZBERG, AR ;

WILKENING, DW .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (08) :1940-1943

[7]

KASINA K, 1990, UNPUB J NUCL MED

[8] SYNTHESIS OF A NOVEL BIFUNCTIONAL CHELATE DESIGNED FOR LABELING PROTEINS WITH TECHNETIUM-99M [J].

LEVER, SZ ;

BAIDOO, KE ;

KRAMER, AV ;

BURNS, HD .

TETRAHEDRON LETTERS, 1988, 29 (26) :3219-3222

[9]

MEARES CF, 1986, INT J RAD APPL INS B, P311

[10] SYNTHESIS OF A NOVEL DIAMINODITHIOL LIGAND FOR LABELING PROTEINS AND SMALL MOLECULES WITH TECHNETIUM-99M [J].

MISRA, HK ;

VIRZI, F ;

HNATOWICH, DJ ;

WRIGHT, G .

TETRAHEDRON LETTERS, 1989, 30 (15) :1885-1888