IMPLANT DELIVERY SYSTEM - INTRALESIONAL DELIVERY OF CHEMOTHERAPEUTIC-AGENTS FOR TREATMENT OF SPONTANEOUS SKIN TUMORS IN VETERINARY PATIENTS

被引：17

作者：

ORENBERG, EK

LUCK, EE

BROWN, DM

KITCHELL, BE

机构：

[1] Matrix Pharmaceutical, Inc., Menlo Park, CA

[2] Department of Comparative Medicine, Stanford University, Stanford, CA

来源：

CLINICS IN DERMATOLOGY | 1991年 / 9卷 / 04期

关键词：

D O I：

10.1016/0738-081X(91)90085-Y

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Anew approach to targeted drug administration using intralesional chemotherapy delivered via therapeutic implant (TI) technology was evaluated in a wide variety of spontaneously occurring skin and subcutaneous tumors in veterinary patients. Many of these animal tumors show similarities in histology and biologic behavior to human epitheliomas and neoplasms and, therefore, serve as appropriate preclinical models for human studies. These animal studies provided valuable insight into this method of local chemotherapy which is now under evaluation with 5-fluorouracil, methotrexate, and cisplatin for treatment of human skin diseases as well as cancer. Administration of free drugs directly into tumors has met with some success in the treatment of superficial lesions including keratoacanthoma,1 basal cell carcinoma,2,3 verruca plantaris,4-6 condyloma acuminatum,6-8 and Kaposi's sarcoma.9 In an effort to improve the response to local chemotherapy we used the therapeutic implant to increase the dose and duration of exposure of selected drugs to tumors, thereby maximizing the therapeutic response while minimizing toxicity to normal tissue. © 1991.

引用

页码：561 / 568

页数：8

共 16 条

[1]

Goette, Odom, Successful treatment of keratoacanthoma with intralesional fluorouracil, J Am Acad Dermatol, 2, pp. 212-216, (1980)

[2]

Kurtis, Rosen, Treatment of cutaneous neoplasms by intralesional injections of 5-fluorouracil (5-FU), J Dermatol Surg Oncol, 6, pp. 122-127, (1980)

[3]

Greenway, Cornell, Tanner, Et al., Treatment of basal cell carcinoma with intralesional interferon, J Am Acad Dermatol, 15, pp. 437-443, (1986)

[4]

Koenig, Horowitz, Verrucae plantaris—Effective treatment with bleomycin: Review of literature and case presentations, J Foot Surg, 21, pp. 108-110, (1982)

[5]

Hayes, O'Keefe, Reduced dose of bleomycin in the treatment of recalcitrant warts, J Am Acad Dermatol, 15, pp. 1002-1006, (1986)

[6]

Vance, Bart, Hansen, Et al., Intralesional recombinant alpha-2 interferon for treatment of patients with condyloma acuminatum or verruca plantaris, Arch Dermatol, 122, pp. 272-277, (1986)

[7]

Figueroa, Gennaro, Intralesional bleomycin injection in treatment of condyloma acuminatum, Dis Colon Rectum, 23, pp. 550-551, (1980)

[8]

Friedman-Kien, Eron, Conant, Et al., Natural interferon for treatment of condylomata acuminata, JAMA, 259, pp. 533-538, (1988)

[9]

Brambilla, Boneschi, Beretta, Et al., Intralesional chemotherapy for Kaposi's sarcoma, Dermatologica, 169, pp. 150-155, (1984)

[10]

Yu, Conley, Luck, Et al., Response of murine tumor to matrix-associated cisplatin intratumoral implants, NCI Monogr, 6, pp. 137-140, (1988)

← 1 2 →