INSULIN-LIKE GROWTH FACTOR-I ACCELERATES RECOVERY FROM ISCHEMIC ACUTE TUBULAR-NECROSIS IN THE RAT

被引:212
作者
MILLER, SB
MARTIN, DR
KISSANE, J
HAMMERMAN, MR
机构
[1] WASHINGTON UNIV, SCH MED, DEPT CELL BIOL & PHYSIOL, ST LOUIS, MO 63110 USA
[2] WASHINGTON UNIV, SCH MED,GEORGE M OBRIEN KIDNEY & UROL DIS CTR, DEPT PATHOL,DIV RENAL, ST LOUIS, MO 63110 USA
关键词
EPIDERMAL GROWTH FACTOR; GROWTH HORMONE; RENAL FAILURE; RENAL REGENERATION;
D O I
10.1073/pnas.89.24.11876
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The effects of administering insulin-like growth factor I (IGF-I) were examined in a model of ischemic acute tubular necrosis in rats. Injury was induced by 75 min of bilateral renal artery occlusion. Compared to rats administered vehicle, rats administered IGF-I (100 mug/day via continuous subcutaneous infusion) had significantly lower serum creatinine and blood urea nitrogen levels over the course of 7 days postocclusion. Glomerular filtration rate as determined by inulin clearance was examined on day 2 postocclusion and was significantly increased in IGF-I-treated animals (0.16 +/- 0.02 ml per min per 100 g of body weight) compared to vehicle-treated controls (0.08 +/- 0.02 ml per min per 100 g of body weight). The weight loss that occurred during the course of acute tubular necrosis was ameliorated by IGF-I. Mortality was reduced from 36.7% in vehicle-treated rats to 7.1% in rats administered IGF-I. Histologically, there was much less renal injury evident at day 7 postocclusion in the IGF-I-treated rats compared to vehicle-treated controls. In contrast, growth hormone (200 mug administered subcutaneously for 4 days) did not affect recovery of renal function or reduce mortality postreperfusion. This report demonstrates a beneficial effect of IGF-I administration in the setting of acute tubular necrosis. Several properties of IGF-I render it a pharmacological agent with excellent potential for treatment of this condition in humans.
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页码:11876 / 11880
页数:5
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