A FIRST APPROACH TO ASYMMETRIC PROTONATION VIA A POLYMER-SUPPORTED CHIRAL PROTON DONOR

被引：32

作者：

CAVELIER, F ^{[1
]}

GOMEZ, S ^{[1
]}

JACQUIER, R ^{[1
]}

VERDUCCI, J ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2,URA 468,F-34095 MONTPELLIER 05,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(00)76652-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric protonation of achiral silyl enol ethers employing chiral proton donors is described for the first time. We have obtained modest enantiomeric excesses by carrying out these reactions in homogeneous solution. The subject of this paper is to report in a preliminary fashion the substantially improved asymmetric induction that can be achieved by supporting the proton donor on a polymeric resin (up to 94% ee). A temperature effect is observed and discussed.

引用

页码：2891 / 2894

页数：4

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