ACETALATION OF D-GLUCITOL - 2,3-5,6-DI-O-ISOPROPYLIDENE-D-GLUCITOL

被引：17

作者：

KUSZMANN, J

SOHAR, P

机构：

[1] Institute for Drug Research, H-1325 Budapest 4

来源：

CARBOHYDRATE RESEARCH | 1979年 / 74卷 / SEP期

关键词：

D O I：

10.1016/S0008-6215(00)84775-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The reaction of d-glucitol with acetone-zinc chloride gave a mixture of isopropylidene derivatives, from which the 2,3:5,6-diacetal (12) could be separated as its 1,4-dimesylate (13) or 1,4-ditosylate (14). The structure of 12 was proved by converting 14, via the 1-mono-iodide, into the known 1-deoxy-d-glucitol, and by mass-spectrometric investigation of the 1-deoxy-4-O-methyl diacetal. The terminally situated acetal group in 12 can be selectively hydrolyzed, and, on treatment with base, the 5,6-dihydroxy derivative obtained gives a d-galactitol 4,5-epoxide derivative. © 1979.

引用

页码：187 / 197

页数：11

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