PSEUDOPRECOCIOUS PUBERTY IN INFANTS CAUSED BY A DERMAL OINTMENT CONTAINING ESTROGENS

被引:50
作者
BEAS, F
VARGAS, L
SPADA, RP
MERCHAK, N
机构
[1] Department of Pediatrics, Universidad de Chile, Hospital Manuel Arriarán, Santiago
[2] Department of Physio-Pathology, Universidad Católica, Santiago
关键词
D O I
10.1016/S0022-3476(69)80113-7
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Seven infants with pseudoprecocious puberty produced by application of an ointment containing estrogens are reported. The clinical findings in these patients were intense pigmentation of the mammillary areola, linea alba of the abdomen, and genitals, mammary enlargement, and pubic hair. The estrogenic activity of this ointment was demonstrated by a biological test. © 1969 The C. V. Mosby Company.
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页码:127 / &
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