EFFECTS OF THE NON-STEROIDAL ANTI-INFLAMMATORY DRUG BENOXAPROFEN ON LEUKOCYTE MIGRATION

被引：72

作者：

MEACOCK, SCR

KITCHEN, EA

机构：

[1] Lilly Research Centre Limited, Windlesham, Surrey, Erl Wood Manor

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1979年 / 31卷 / 06期

关键词：

D O I：

10.1111/j.2042-7158.1979.tb13524.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Possible modes of action of the anti‐inflammatory drug, benoxaprofen, have been explored. The drug caused inhibition of leucocyte migration, principally of mononuclear cells into the pleural cavity of rats undergoing carrageenan‐induced pleurisy. Evidence was obtained from in vitro leucocyte migration and chemotaxis models that the drug acted directly on the mononuclear cells rather than by inhibition of chemotactic factors. 1979 Royal Pharmaceutical Society of Great Britain

引用

收藏

页码：366 / 370

页数：5

相关论文

共 12 条

[1] EFFECT OF ANTI-INFLAMMATORY DRUGS ON ENZYMIC ACTIVITY OF A RAT LIVER GRANULAR FRACTION WHICH INCREASES VASCULAR PERMEABILITY [J].

ANDERSON, AJ .

BIOCHEMICAL PHARMACOLOGY, 1968, 17 (11) :2253-+

[2] PHARMACOLOGY OF BENOXAPROFEN (2-[4-CHLOROPHENYL]-ALPHA-METHYL-5-BENZOXAZOLE ACETIC-ACID), LRCL-3794, A NEW COMPOUND WITH ANTI-INFLAMMATORY ACTIVITY APPARENTLY UNRELATED TO INHIBITION OF PROSTAGLANDIN SYNTHESIS [J].

CASHIN, CH ;

DAWSON, W ;

KITCHEN, EA .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1977, 29 (06) :330-336

[3] DISPOSITION AND METABOLISM OF BENOXAPROFEN IN LABORATORY-ANIMALS AND MAN [J].

CHATFIELD, DH ;

GREEN, JN .

XENOBIOTICA, 1978, 8 (03) :133-144

[4]

DIROSA M, 1972, J PATHOL, V105, P239

[5] SEPARATE ANTI-INFLAMMATORY EFFECTS OF INDOMETHACIN, FLURBIPROFEN AND BENOXAPROFEN [J].

FORDHUTCHINSON, AW ;

WALKER, JR ;

CONNOR, NS ;

OLIVER, AM ;

SMITH, MJH .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1977, 29 (06) :372-373

[6]

GEORGE M, 1962, P SOC EXP BIOL MED, V111, P514

[7] EFFECTS OF ANTI-INFLAMMATORY DRUGS ON STABILITY OF RAT LIVER LYSOSOMES IN-VITRO [J].

IGNARRO, LJ .

BIOCHEMICAL PHARMACOLOGY, 1971, 20 (10) :2847-+

[8] SOME EFFECTS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON LEUKOCYTE MIGRATION [J].

MEACOCK, SCR ;

KITCHEN, EA .

AGENTS AND ACTIONS, 1976, 6 (1-3) :320-325

[9] EFFECT OF BOVINE SERUM-ALBUMIN ON INVITRO INHIBITION OF CHEMOTAXIS BY ANTI-INFLAMMATORY AGENTS [J].

RIVKIN, I .

AGENTS AND ACTIONS, 1977, 7 (04) :465-468

[10]

THOMPSON RA, 1968, IMMUNOLOGY, V14, P745