DECREASE IN THE RAT BRONCHIAL ACETYLCHOLINESTERASE ACTIVITY AFTER TOLUENE DIISOCYANATE INHALATION

被引：3

作者：

BRONDEAU, MT

BAN, M

SIMON, P

BONNET, P

DECEAURRIZ, J

机构：

[1] Institut National de Recherche et de Sécurité, Vandoeuvre

来源：

JOURNAL OF APPLIED TOXICOLOGY | 1990年 / 10卷 / 06期

关键词：

acetylcholinesterase; bronchial tissue; toluene diisocyanate;

D O I：

10.1002/jat.2550100608

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Acetylcholinesterase (AChE) activity was measured in bronchial tissue homogenate and blood from rats subjected to single and repeated 4‐h daily inhalation exposure to toluene diisocyanate (TDI) or control atmospheres. A single 4‐h exposure to TDI in the concentration range of 0.7–4.3 ppm did not decrease AChE activity in bronchial tissue but a 4‐h exposure to 0.6 ppm TDI, or greater, for two consecutive days did reduce this activity (19% to 33% of the controls). Increasing the level of exposure to TDI for two consecutive days from 0.6 to 4.0 ppm and extending the length of exposure to 1.2 ppm TDI from 2 to 4, 9 or 14 days produced no further decrease in bronchial ACHE activity. Throughout these experiments, blood AChE activity remained unchanged. In rats exposed to 0.3 or 1 ppm TDI for 3 weeks, staining of the bronchial smooth muscle for AChE was reduced (36% of the controls) after exposure to 1 ppm TDI. These results support, for the first time, in vivo and localized anti‐AChE activty by TDI. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：423 / 427

页数：5

共 21 条

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