BREAKDOWN OF SELF-TOLERANCE IN ANERGIC LYMPHOCYTES-B

被引：221

作者：

GOODNOW, CC

BRINK, R

ADAMS, E

机构：

[1] STANFORD UNIV, HOWARD HUGHES MED INST, STANFORD, CA 94305 USA

[2] STANFORD UNIV, DEPT MICROBIOL & IMMUNOL, STANFORD, CA 94305 USA

来源：

NATURE | 1991年 / 352卷 / 6335期

关键词：

D O I：

10.1038/352532a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

PRODUCTION of autoantibodies, which characterizes most autoimmune diseases, is normally avoided by active elimination 1-7 or functional inactivation (anergy) 8-15 of B and T lymphocytes bearing receptors for self antigens. The mechanisms leading to the escape of self-reactive clones from these normal tolerance mechanisms in autoimmune diseases nevertheless remain obscure. Here, we demonstrate that clonal anergy in B lymphocytes is a reversible process, and that silenced self-reactive B cells can be reactivated under particular conditions to give rise to vigorous antibody responses. Reactivation of anergic lymphocytes may explain many examples of transient autoimmune reactions in normal individuals, and may under pathological conditions be important in the development of chronic autoimmune disease.

引用

收藏

页码：532 / 536

页数：5

相关论文

共 24 条

[1] INTRINSIC B-CELL HYPORESPONSIVENESS ACCOUNTS FOR SELF-TOLERANCE IN LYSOZYME ANTILYSOZYME DOUBLE-TRANSGENIC MICE [J].

ADAMS, E ;

BASTEN, A ;

GOODNOW, CC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (15) :5687-5691

[2]

[Anonymous], 1959, CLONAL SELECTION THE, DOI DOI 10.5962/BHL.TITLE.8281

[3] A ROLE FOR CLONAL INACTIVATION IN T-CELL TOLERANCE TO MLS-1A [J].

BLACKMAN, MA ;

BURGERT, HG ;

WOODLAND, DL ;

PALMER, E ;

KAPPLER, JW ;

MARRACK, P .

NATURE, 1990, 345 (6275) :540-542

[4] SELF-TOLERANCE TO TRANSGENIC-GAMMA-DELTA-T-CELLS BY INTRATHYMIC INACTIVATION [J].

BONNEVILLE, M ;

ISHIDA, I ;

ITOHARA, S ;

VERBEEK, S ;

BERNS, A ;

KANAGAWA, O ;

HAAS, W ;

TONEGAWA, S .

NATURE, 1990, 344 (6262) :163-165

[5] T-CELL TOLERANCE BY CLONAL ANERGY IN TRANSGENIC MICE WITH NONLYMPHOID EXPRESSION OF MHC CLASS-II I-E [J].

BURKLY, LC ;

LO, D ;

KANAGAWA, O ;

BRINSTER, RL ;

FLAVELL, RA .

NATURE, 1989, 342 (6249) :564-566

[6] A SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE)-LIKE DISEASE IN MICE INDUCED BY ABNORMAL T-B-CELL COOPERATION - PREFERENTIAL FORMATION OF AUTOANTIBODIES CHARACTERISTIC OF SLE [J].

GLEICHMANN, E ;

VANELVEN, EH ;

VANDERVEEN, JPW .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1982, 12 (02) :152-159

[7] DISEASES CAUSED BY REACTIONS OF T LYMPHOCYTES TO INCOMPATIBLE STRUCTURES OF MAJOR HISTOCOMPATIBILITY COMPLEX .1. AUTOIMMUNE HEMOLYTIC-ANEMIA [J].

GLEICHMANN, E ;

GLEICHMANN, H .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1976, 6 (12) :899-906

[8] INDUCTION OF SELF-TOLERANCE IN MATURE PERIPHERAL LYMPHOCYTES-B [J].

GOODNOW, CC ;

CROSBIE, J ;

JORGENSEN, H ;

BRINK, RA ;

BASTEN, A .

NATURE, 1989, 342 (6248) :385-391

[9] ALTERED IMMUNOGLOBULIN EXPRESSION AND FUNCTIONAL SILENCING OF SELF-REACTIVE LYMPHOCYTES-B IN TRANSGENIC MICE [J].

GOODNOW, CC ;

CROSBIE, J ;

ADELSTEIN, S ;

LAVOIE, TB ;

SMITHGILL, SJ ;

BRINK, RA ;

PRITCHARDBRISCOE, H ;

WOTHERSPOON, JS ;

LOBLAY, RH ;

RAPHAEL, K ;

TRENT, RJ ;

BASTEN, A .

NATURE, 1988, 334 (6184) :676-682

[10] INDUCTION OF MURINE AUTOIMMUNE-DISEASE BY CHRONIC POLYCLONAL B-CELL ACTIVATION [J].

HANG, L ;

SLACK, JH ;

AMUNDSON, C ;

IZUI, S ;

THEOFILOPOULOS, AN ;

DIXON, FJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 157 (03) :874-883