CHRONIC CONTINUOUS NICOTINE TREATMENT CAUSES DECREASED BURST FIRING OF NIGRAL DOPAMINE NEURONS IN RATS PARTIALLY HEMITRANSECTED AT THE MESO-DIENCEPHALIC JUNCTION

被引：22

作者：

GRENHOFF, J

JANSON, AM

SVENSSON, TH

FUXE, K

机构：

[1] KAROLINSKA INST, DEPT HISTOL & NEUROBIOL, POB 60400, S-10401 STOCKHOLM 60, SWEDEN

[2] KAROLINSKA INST, DEPT PHARMACOL, S-10401 STOCKHOLM 60, SWEDEN

来源：

BRAIN RESEARCH | 1991年 / 562卷 / 02期

关键词：

BURST FIRING; DOPAMINE; FIRING PATTERN; LESION; NICOTINE; PROTECTION; SINGLE CELL RECORDING; SUBSTANTIA-NIGRA;

D O I：

10.1016/0006-8993(91)90646-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chronic continuous administration of nicotine (0.125 mg/kg/h, 14 days) to male Sprague-Dawley rats with a partial hemitransection at the meso-diencephalic junction caused a significant reduction in burst firing of remaining dopamine (DA) neurons in the zona compacta, substantia nigra, whereas neither the firing rate nor the number of spontaneously active DA cells per track were altered in comparison with saline-treated, hemitransected controls. The reduced functional activity of the remaining DA cells subjected to nicotine treatment provides a physiological correlate to the previously observed, reduced DA utilization in these neurons. It may also help to explain the increased nigral DA cell survival found after chronic nicotine treatment in similar lesion experiments.

引用

页码：347 / 351

页数：5

共 31 条

[1] GANGLIOSIDES INCREASE THE SURVIVAL OF LESIONED NIGRAL DOPAMINE NEURONS AND FAVOR THE RECOVERY OF DOPAMINERGIC SYNAPTIC FUNCTION IN STRIATUM OF RATS BY COLLATERAL SPROUTING [J].